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dc.contributor.authorSilveira, Marina Bicalho-
dc.contributor.authorFerreira, Soraya M. Z. M. D.-
dc.contributor.authorNascimento, Leonardo T. C.-
dc.contributor.authorMendes, Bruno Melo-
dc.contributor.authorFerreira, Andréa Vidal-
dc.contributor.authorMalamut, Carlos-
dc.contributor.authorSilva, Juliana Batista-
dc.contributor.authorMamede, Marcelo Henrique-
dc.date.accessioned2018-01-19T09:44:01Z-
dc.date.available2018-01-19T09:44:01Z-
dc.date.issued2016-
dc.identifier.citationSilveira, M.B. et al. Preclinical acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [18F]fluorocholine in mice, Applied Radiation and Isotopes, 116, pp. 92-101, 2016.pt_BR
dc.identifier.issn0969-8043pt_BR
dc.identifier.urihttp://www.repositorio.cdtn.br:8080/jspui/handle/123456789/1246-
dc.description.abstract[18F]Fluorocholine ([18F]FCH) has been proven to be effective in prostate cancer. Since [18F]FCH is classified as a new radiopharmaceutical in Brazil, preclinical safety and efficacy data are required to support clinical trials and to obtain its approval. The aim of this work was to perform acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [18F]FCH. The results could support its use in nuclear medicine as an important piece of work for regulatory in Brazil.pt_BR
dc.format.extent92-101pt_BR
dc.language.isoen_USpt_BR
dc.rightsRpt_BR
dc.subjectOrganic fluorine compoundspt_BR
dc.subjectCholinept_BR
dc.subjectComputerized tomographypt_BR
dc.subjectClinical trialspt_BR
dc.subjectDosimetrypt_BR
dc.subjectFluorine 18pt_BR
dc.subjectNeoplasmspt_BR
dc.subjectToxicitypt_BR
dc.subjectRadiopharmaceuticalspt_BR
dc.subjectToxicitypt_BR
dc.subjectProstetept_BR
dc.titlePreclinical acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [18F]fluorocholine in micept_BR
dc.typeArtigo Periódicopt_BR
dc.coverageIpt_BR
dc.creator.affiliationCentro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasilpt_BR
dc.creator.affiliationCentro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasilpt_BR
dc.creator.affiliationCentro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasilpt_BR
dc.creator.affiliationCentro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasilpt_BR
dc.creator.affiliationCentro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasilpt_BR
dc.creator.affiliationCentro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasilpt_BR
dc.creator.affiliationUniversidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasilpt_BR
dc.identifier.vol116pt_BR
dc.title.journalApplied Radiation and Isotopespt_BR
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