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Campo DC | Valor | Idioma |
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dc.contributor.author | Menezes, D.C. | |
dc.contributor.author | Vieira, F.T. | |
dc.contributor.author | Lima, G.M. de | |
dc.contributor.author | Wardell, J.L. | |
dc.contributor.author | Cortés, M.E. | |
dc.contributor.author | Ferreira, Max Passos | |
dc.contributor.author | Vilas Boas, A. | |
dc.date.accessioned | 2016-08-29T18:47:09Z | - |
dc.date.available | 21-10-2010 | |
dc.date.available | 2016-08-29T18:47:09Z | - |
dc.date.issued | 2008 | |
dc.identifier.issn | ISSN 0268; 1099-0739 | |
dc.identifier.uri | http://www.repositorio.cdtn.br:8080/jspui/handle/123456789/398 | - |
dc.description.abstract | The in vitro antifungal activity of the dithiocarbamate organotin complexes [Sn{S2CN(CH2)4}2Cl2] (1), [Sn{S2CN(CH2)4}2Ph2] (2), [Sn{S2CN(CH2)4}Ph3] (3), [Sn{ S2CN(CH2)4}2n-Bu2] (4), [Sn{ S2CN(CH2)4}Cy3] {Cy = cyclohexyl} (5), [Sn{S2CN(C2H5)2}2Cl2] (6), [Sn{S2CN(C2H5)2}2Ph2] (7), [Sn{S2CN(C2H5)2}Ph3] (8), [Sn{S2CN(C2H5)2}3Ph] (9) and [Sn{S2CN(C2H5)2}Cy3] (10) has been screened against Candida albicans (ATCC 18804), Candida tropicalis (ATCC 750) and resistant Candida albicans collected from HIV-positive Brazilian patients with oral candidiasis. All compounds exhibited antifungal activities and complexes 3 and 8 displayed the best results. We have investigated the effect of compounds 1-10 on the cellular activity of the yeast cultures. Changes in mitochondrial function have not been detected. However, all drugs reduced ergosterol biosynthesis. Preliminary studies on DNA integrity indicated that the compounds do not cause gross damage to yeast DNA. The data suggest that these compounds share some mechanisms of action on cell membranes similar to that of polyene but not with azole drugs, normally used in Candida infections. | |
dc.language.iso | Inglês | |
dc.rights | L | |
dc.subject | Fungi | |
dc.subject | candida | |
dc.subject | carbamates | |
dc.title | The in vitro antifungal activity of some dithiocarbamate organotin (IV) compounds on Candida albicans- a model for biological interaction of organotin complexes | |
dc.type | Artigo Periódico | |
dc.creator.affiliation | Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil | |
dc.creator.affiliation | Universidade Federal de minas Gerais/UFMG, Belo Horizonte, MG, Brasil | |
dc.creator.affiliation | Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil | |
dc.creator.affiliation | Universitaet of Aberdeen, Old Aberdeen, Scotland, UK | |
dc.creator.affiliation | Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil | |
dc.creator.affiliation | Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil | |
dc.creator.affiliation | Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil | |
dc.identifier.fasciculo | 4 | |
dc.identifier.vol | 22 | |
dc.identifier.extent | p.221-226 | |
dc.title.journal | Applied Organometalic Chemistry Sussex | |
Aparece nas coleções: | Artigo de periódico |
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