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http://www.repositorio.cdtn.br:8080/jspui/handle/123456789/1246| Title: | Preclinical acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [18F]fluorocholine in mice |
| Title of periodic: | Applied Radiation and Isotopes |
| Authors: | Silveira, Marina Bicalho Ferreira, Soraya M. Z. M. D. Nascimento, Leonardo T. C. Mendes, Bruno Melo Ferreira, Andréa Vidal Malamut, Carlos Silva, Juliana Batista Mamede, Marcelo Henrique |
| Affiliation: | Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil |
| Issue Date: | 2016 |
| Keywords: | Organic fluorine compounds;Choline;Computerized tomography;Clinical trials;Dosimetry;Fluorine 18;Neoplasms;Toxicity;Radiopharmaceuticals;Toxicity;Prostete |
| Abstract: | [18F]Fluorocholine ([18F]FCH) has been proven to be effective in prostate cancer. Since [18F]FCH is classified as a new radiopharmaceutical in Brazil, preclinical safety and efficacy data are required to support clinical trials and to obtain its approval. The aim of this work was to perform acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [18F]FCH. The results could support its use in nuclear medicine as an important piece of work for regulatory in Brazil. |
| Access: | R |
| Appears in Collections: | Artigo de periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Preclinical acute toxicity biodistribution.pdf | 1.15 MB | Adobe PDF | View/Open Request a copy |
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