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Title: Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline
Title of periodic: Journal of Radioanalytical and Nuclear Chemistry
Authors: Leal, Alexandre Soares
Marzano, Ivana Marques
Pereira-Maia, Elene Cristina P.
Jačimović, Radojko
Affiliation: Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil
Jozef Stefan Institute, Ljubljana, Slovenia
Issue Date: 2016
Keywords: SENSITIZERS Blood cells;Chemotherapy;Neoplasms;Platinum complexes;Radiotherapy;Sensitizers
Abstract: The proposal of this work was to investigate the effect of the radioactive complex of platinum(II) with tetracycline, [PtCl2(C22H24N2O8)]*, or [Tc–Pt(II)]*, on K562 cells—blood human cells of leukemia—and verify if the internal radio-chemotherapy would be able to produce additional effects compared with the non-labelled complex, [PtCl2(C22H24N2O8)], or [Tc–Pt(II)]. The concentration required to inhibit 50 % of cellular growth, (IC50), was 2.5 ± 0.2 µM for [Tc–Pt(II)]* and 14.5 ± 0.9 µM for the non-labelled molecule [Tc–Pt(II)]. This result suggest that the [Tc–Pt(II)]* could be a potent radiosensitizer evoking a supra additive effect. Treatment using the internal radio-chemotherapy may be a useful alternative to reduce the drug concentration required for effective inhibition of the tumor growth.
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