Please use this identifier to cite or link to this item:
Title: Synthesis and characterization of calcium phosphate loaded with Ho-166 and Sm-153: a novel biomaterial for treatment of spine metastases
Title of periodic: Journal of materials science - materials in medicine
Authors: Donanzam, B. A.
Campos, T. P. R.
Dalmázio, Ilza
Valente, E. S
Affiliation: Universidade Federal de Minas Gerais, UFMG, Belo Horizonte MG, Brasil
Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo horizonte, MG, Brasil
Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brasil
Issue Date: 2013
Keywords: Tricalcium phosphate;Bone;Hydroxyapatite
Abstract: Spine metastases are a common and painful complication of cancer. A novel concept of treatment combines the in situ vertebroplasty with radiotherapy employing radioactive bone cement into the human vertebrae. Thus, investigations concerning possible bioactive and radioactive cements become a relevant theme. In this work, we have synthesized calcium phosphate bioceramics incorporated with Ho and Sm nuclides using sol-gel technique. Characterizations were performed using X-ray diffractometry, infrared spectroscopy, scanning electron microscopy, instrumental neutron activation analysis, and gamma spectroscopy. Results showed bioceramics composed by multiphasic calcium phosphates along with holmium and samarium phosphates, with 8.9 and 13.7 % of Sm and Ho in weight, respectively. After neutron activation, the Ho-166 and Sm-153 beta-emitters were identified and quantified on the bioceramics with activities estimated at 32.5 and 14.5 MBq/mg of Sm-153 and Ho-166 bioceramic powder, respectively. These radioactive calcium phosphate bioceramics can compose suitable radioactive cements to radiovertebroplasty.
Access: L
Appears in Collections:Artigo de periódico

Files in This Item:
File Description SizeFormat 
Synthesis and characterization of calcium phosphate loaded.pdf380.3 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.