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http://www.repositorio.cdtn.br:8080/jspui/handle/123456789/433| Title: | Production of the radioactive antitumoral cisplatin |
| Title of periodic: | Applied Radiation and Isotopes |
| Authors: | Leal, Alexandre Soares Carvalho Júnior, Álvaro D. Abrantes, Fabiana M. Menezes, Maria Ângela de Barros Correia Ferraz, Vany Cruz, Tamara S. Cardoso, Valbert N. Oliveira, Mônica C. de |
| Affiliation: | Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil; Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil |
| Issue Date: | 2006 |
| Keywords: | Platinum complexes;labelled compounds;TRIGA-Brazil reactor |
| Abstract: | This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDDP, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP and suggest that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug. |
| Access: | L |
| Appears in Collections: | Artigo de periódico |
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