Please use this identifier to cite or link to this item: http://www.repositorio.cdtn.br:8080/jspui/handle/123456789/448
Title: Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study
Title of periodic: Brazilian Archives of Biology and Technology
Authors: Carvalho Júnior, Álvaro Dutra de
Abrantes, Fabiana Moreira
Menezes, Maria Ângela de Barros Correia
Leal, Alexandre Soares
Cardoso, Valbert Nascimento
Oliveira, Mônica Cristina de
Affiliation: Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil
Centro de Desenvolvimento da Tecnologia Nuclear/CDTN, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais/UFMG, MG, Brasil
Issue Date: 2005
Keywords: Platinum complexes;labelled compounds;TRIGA-Brazil reactor
Abstract: This paper presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP, from its direct irradiation into a cadmium capsule, using TRIGA Mark I IPR R-1 research reactor of the CDTN. The ability to detect CDDP in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP was taken up principally by liver, spleen and kidney. The CDDP obtained from this condition was shown to be a good tool for biodistribution studies.
Access: L
Appears in Collections:Artigo de periódico

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